Immunisation Dtp Polio Hep B And Hib
Overview
The 6-in-1 vaccine is a single injection that protects babies against six serious infections at once: diphtheria, tetanus, whooping cough (pertussis), polio, hepatitis B and Hib (Haemophilus influenzae type b). It is given to babies in the first few months of life, when they are most vulnerable to these illnesses. The vaccine contains killed (inactive) or harmless parts of the germs, so it cannot cause the diseases it protects against. Instead, it teaches your baby's immune system to recognise and fight those germs if they ever meet them for real.
Key facts
- One small injection protects against six diseases, which means fewer needles for your baby.
- It is usually offered at 8, 12 and 16 weeks of age, with a booster before school starts.
- The vaccine is very safe. The most common effects are a sore, red spot on the leg and a mild temperature, which settle within a day or two.
- The diseases it prevents can be life-threatening in babies, so protecting them early matters.
Yes. This vaccine is offered to every baby as part of the routine childhood schedule, so your nurse or doctor will be very used to giving it. Millions of babies receive it each year.
Babies from around 8 weeks old, and young children when they have their pre-school booster. Some adults also need boosters against one or more of these diseases — for example during pregnancy, for certain jobs, or before travelling to places where these illnesses are more common.
Symptoms
- Swelling of the face, lips, tongue or throat
- Difficulty breathing, noisy breathing or a hoarse, croaky cry with breathing trouble
- Sudden collapse, going limp, or being very hard to wake
- A severe allergic reaction can happen within minutes of any injection. It is extremely rare, but if you see these signs, call your local emergency number straight away.
- ⚠A temperature of 38°C or higher in a baby under 3 months old
- ⚠A temperature that lasts more than 2 to 3 days
- ⚠A very high-pitched, continuous cry that you cannot settle, lasting 3 hours or more
- ⚠A seizure (fit) or jerking movements
- ⚠Redness or swelling that keeps spreading or looks infected
- ⚠Your baby seems floppy, very pale, or is not feeding at all
Common symptoms
- A sore, red or slightly swollen area on the thigh where the injection went in
- A mild temperature (slightly raised body heat)
- Being more fussy or unsettled than usual
- Being sleepier than usual, or sometimes more wakeful
- Feeding a little less than normal for a day
- A small hard lump at the injection site that can last a few weeks
Symptoms in children
- Crying more than usual, especially in the first few hours
- Wanting extra cuddles and comfort
- Being off their food for a day
- A red, warm patch on the leg that slowly fades
- Temporary swelling of the whole thigh happens occasionally and settles on its own
Symptoms in older adults
- This vaccine is mainly for babies and young children. When older children or adults need a booster of one of these vaccines, a sore arm and a mild temperature for a day or two are the usual effects.
Causes
Main causes
- This page is about a vaccine, not an illness, so it does not have 'causes' in the usual sense. The vaccine works by showing your baby's immune system a safe version of each germ.
- Diphtheria, tetanus, whooping cough and Hib are caused by bacteria. Polio and hepatitis B are caused by viruses.
- These germs spread easily between people — through coughs and sneezes, or through contact with an infected person. Babies have not yet built up protection, which is why vaccination starts so early.
Risk factors
- Being very young — babies under 6 months are at the highest risk of severe complications from whooping cough and Hib
- Not being vaccinated, or having only part of the course
- Being born prematurely, which can make some infections more serious
- Living with a condition or receiving treatment that weakens the immune system (your doctor will advise on timing)
- Travel or close contact with people from areas where these diseases are more common
When to see a doctor
See a doctor urgently if:
- Your baby has a fever of 38°C or above and is under 3 months old
- Your baby has a fit, becomes floppy, or is very difficult to wake
- Your baby's breathing seems different — fast, noisy or laboured
- There is severe swelling of the leg or the redness is spreading quickly
- Your baby has a high-pitched, inconsolable cry for several hours
Book a routine appointment if:
- You are worried about any reaction, even a mild one — it is always fine to ask
- Your baby missed a dose or you are not sure what is next in the schedule
- Your baby was unwell on the day of the appointment, or has a long-term condition
- You have questions about the ingredients, or about vaccines in general
- A lump at the injection site is still there after a few weeks
Diagnosis
There is nothing to diagnose here — this is a protective vaccine, not a test for an illness. Before the injection, the nurse or doctor will ask a few quick questions about your baby's health and check they are well enough to have it that day.
Tests that may be done
- No blood tests or scans are needed
- The nurse will check your baby's temperature and general health on the day
- Your baby's personal health record (often a red book) is updated so the doses are recorded correctly
What to expect at your appointment
The appointment is short. The nurse will ask about any illness or allergies, explain what is being given, and then give the injection into your baby's thigh — this is the safest spot for a baby. Your baby will probably cry briefly. You can feed or cuddle them straight afterwards. You will be given advice on what to expect and when the next dose is due. Sometimes several vaccines are given at the same visit, in different legs.
Treatment
No treatment is needed after the vaccine — it is doing its job. Any mild reactions can be eased at home with comfort and, if needed, advice from a pharmacist or nurse about suitable fever and pain relief for your baby's age.
Self-care at home
- Give plenty of cuddles and keep your baby close
- Offer extra feeds — babies who feed well tend to settle better
- Dress your baby in light, comfortable clothing if they feel warm
- Do not rub or massage the injection site
- A cool (not cold) cloth on the leg can be soothing if your baby seems to like it
- Keep a note of the time and dose of any fever medicine you give, so you do not give more than recommended
- Never give aspirin to a child under 16
Medical treatments
If your baby seems uncomfortable or has a mild temperature, ask your pharmacist, nurse or doctor which pain and fever relief is suitable for your baby's age and weight, and follow their advice carefully. Your surgery can also advise if you are unsure whether a reaction is normal. Severe allergic reactions are treated in hospital with emergency medicines, but this is extremely rare.
Living with this condition
Life carries on as normal after the injection. Your baby can be fed, cuddled, bathed and taken out as usual. Many parents find the first 24 hours are the fussiest, and things settle quickly after that. Keeping your appointments and your baby's health record up to date makes the whole schedule much easier to manage.
Lifestyle tips
- Keep a simple record of each vaccine, with the date, so you always know what is next
- Try to book appointments at a time when your baby is usually calm and well rested
- Bring a favourite blanket, toy or dummy to the appointment for comfort
- If your baby is due other vaccines at the same visit, it is fine to ask which is which
- Hand-washing and keeping away from people with coughs and colds also helps protect young babies
Diet and exercise
No special diet is needed. Continue your baby's usual milk feeds, and offer extra feeds if they seem unsettled or warm. Normal play and movement are fine — there is no need to rest the leg. For older children, ordinary running about is encouraged.
Mental health and emotional wellbeing
It is very common for parents to feel anxious before their baby's injections, and hearing your baby cry can be upsetting. Those feelings are normal and usually pass quickly. If worry about vaccines is weighing on you, or you have had a difficult experience, talk it through with your health visitor, nurse or doctor. They will not judge you — they would much rather answer your questions. If low mood or anxiety is affecting your daily life, please reach out for support, and remember that crisis support is available in every country if you ever feel you cannot cope.
Prevention
Yes — vaccination is one of the most effective ways to prevent these six diseases. When enough babies are vaccinated, the germs have nowhere to spread, which also protects newborn babies who are too young to be vaccinated and people who cannot have vaccines for medical reasons.
Vaccines
The 6-in-1 vaccine is usually given at 8, 12 and 16 weeks of age, with a booster before your child starts school (around 3 years and 4 months). Some babies with certain health conditions are offered an extra dose at birth or later. Whooping cough vaccine is also offered in pregnancy, which passes protection to the newborn baby before their own vaccines start. Ask your nurse or doctor about the exact schedule where you live, and about catch-up doses if you have missed any.
Complications
If left untreated
- Whooping cough causes severe coughing fits and pauses in breathing in babies, and can be life-threatening in the first few months of life
- Hib can cause meningitis (swelling around the brain) and epiglottitis (a dangerous swelling of the throat that blocks breathing)
- Diphtheria can block the airway and damage the heart and nerves
- Tetanus causes painful muscle stiffness and spasms, and can be fatal
- Polio can cause permanent weakness or paralysis
- Hepatitis B can lead to long-term liver damage and liver cancer
- Not being vaccinated also leaves other people at risk, especially newborn babies and those who cannot be protected themselves
Long-term outlook
The outlook for a vaccinated child is excellent. These vaccines have been used for decades and have made these diseases rare in many parts of the world. If your baby has a mild reaction, it passes quickly and is a sign the immune system is learning. If you have missed doses, it is not too late — catch-up vaccination works well, so talk to your nurse or doctor about getting back on track.
Find support
External links open third-party websites. Ruqelo Health is not responsible for external content. Listing an organisation does not imply endorsement.
Always verify with your doctor
Health guidance differs by country and region. This page is general education and may not match the guidelines, medicines, or practice where you live. Discuss your concerns with your own doctor or healthcare provider, and follow local guidance where it exists.
Important notice This information is for educational purposes only. It does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider about your specific situation. If you are experiencing a medical emergency, call your local emergency services immediately.
Related conditions
Sources and guidance
No guideline names this topic
No health guideline or clinical chapter that names this exact topic is cited here. This page is for general education and information only. It is not a diagnosis, a treatment plan, or personal medical advice. Check with your own doctor and follow their advice. If symptoms are severe, sudden, or worrying, get medical care promptly, and call your local emergency number in an emergency. Ruqelo LLC is not responsible for medical or legal outcomes from decisions based on this information.
Last updated: October 24, 2026
Educational note: This information is for education only and is not a diagnosis.
Use it to support, not replace, advice from a licensed clinician.
If symptoms are severe, worsening, or urgent, call your local emergency number or seek emergency care.
Guidance may differ by country or region. Confirm local recommendations with a qualified healthcare provider.