Kambo
Overview
Kambo (also called 'frog poison' or 'sapo') is a substance taken from the skin of a frog that lives in the Amazon rainforest. It is not a medicine and has not been approved to treat or cure any illness. It is used in ceremonies where a practitioner makes small burns on the skin, usually on the arm, leg or chest, and puts the substance onto the fresh burns. This is often described online as a 'detox' or 'cleanse'. Within minutes, most people feel very unwell — flushed, sick, and with a racing heart — for a few hours. The substance contains peptides, which are small proteins that affect the heart, blood vessels, gut and brain. Serious reactions, including deaths, have been reported, so it is important to know the risks.
Key facts
- Kambo is not a medicine. There is no good evidence that it treats, cures or 'detoxes' any health condition.
- It is placed on small burns made in the skin during a ceremony, and it usually causes intense vomiting, diarrhoea and a racing heartbeat.
- Serious harm has been reported, including dangerously low salt levels, seizures, heart problems and deaths — even in people who were previously healthy.
Kambo is not used in mainstream healthcare and most doctors rarely or never see a case. However, it has become more popular in some wellness and alternative-health circles, and through social media and retreats. So while it is uncommon overall, you may hear about it from friends or online.
Mostly adults who take part in alternative health retreats or ceremonies. Some groups are at much higher risk: people with heart conditions, low blood pressure, epilepsy, kidney problems, or mental health conditions; people who are pregnant or breastfeeding; children and teenagers; and older adults. Anyone taking regular medicines should check with a doctor or pharmacist first, because some medicines can make reactions worse.
Symptoms
- Swelling of the face, lips, tongue or throat, or difficulty breathing or swallowing
- Chest pain, or a very fast or irregular heartbeat
- A seizure or fit
- Fainting, collapse, or being very hard to wake
- Confusion, odd behaviour, or a sudden severe headache
- Vomiting that will not stop, or being unable to keep any fluids down
- Passing little or no urine, or severe muscle weakness
- A severe allergic-type reaction with widespread rash and feeling very unwell
- ⚠A high fever
- ⚠Redness, swelling, heat, pus or spreading pain at the burn marks
- ⚠Feeling faint when you stand up
- ⚠Muscle cramps, twitching or unusual numbness
- ⚠Feeling very unwell for more than a day after the session
Common symptoms
- Feeling very hot and flushed, with swelling of the face, lips or around the eyes
- Feeling sick and vomiting, sometimes many times over a few hours
- Diarrhoea
- A fast, pounding or fluttering heartbeat
- Dizziness, light-headedness or feeling faint
- Sweating, shivering or feeling cold and clammy
- A strange taste, numbness or tingling in the mouth
- Feeling very tired, shaky or weak afterwards
- Soreness, blistering or small scars at the burn marks
Symptoms in children
- Children can become dehydrated much faster from vomiting and diarrhoea
- Dangerously low salt (sodium) levels in the blood can develop quickly
- They may not be able to explain how unwell they feel
- Kambo should not be given to children or teenagers at all
Symptoms in older adults
- A higher chance of heart rhythm problems and a sudden drop in blood pressure
- Medicines for blood pressure or fluid balance can make reactions stronger
- Less reserve to cope with losing water and salts
- Confusion or falls if blood pressure drops
Causes
Main causes
- Taking kambo — the dried substance from a frog's skin, placed on small burns made in the skin
- The peptides in it affect the heart, blood vessels, gut and brain, causing sudden, strong body reactions
- Heavy vomiting and diarrhoea, which drain water and salt from the body
- Not replacing salts properly before or after a session, or fasting for a long time around it
Risk factors
- Heart conditions, including irregular heartbeats
- Low blood pressure or a history of fainting
- Epilepsy or any history of seizures
- Kidney disease
- Pregnancy or breastfeeding
- Mental health conditions such as anxiety, panic or low mood
- Taking regular medicines, especially those for blood pressure, mood or fluid balance — ask your pharmacist
- Being a child, teenager or older adult
- Fasting, dehydration, or very hot conditions during the ceremony
- A practitioner with no medical training, in a place far from medical help
- Doing more than one session, or a large amount at once
When to see a doctor
See a doctor urgently if:
- You took part in kambo and now feel very unwell, faint, confused, or cannot keep fluids down
- You have any of the emergency symptoms listed above — call your local emergency number straight away
- A burn mark becomes hot, red, swollen, weepy or the redness is spreading
- You have cramps, twitching, unusual thirst or are passing very little urine
Book a routine appointment if:
- You are thinking about trying kambo and want to talk it through with a doctor or pharmacist first
- You feel anxious, low, panicky or shaken after a session
- You have lasting tiredness, muscle cramps or unusual thirst
- A burn mark has left a scar that bothers you
- You want help for the health problem that made you consider kambo in the first place
Diagnosis
There is no test for kambo itself. A doctor works out what is happening from your story — what you took, when, how much, and how you felt afterwards — together with a physical examination and tests to check your heart, kidneys and salt levels. This is why telling staff exactly what happened matters so much.
Tests that may be done
- Blood tests to check salt levels (especially sodium), kidney function and muscle enzymes
- An electrocardiogram (ECG) to check the heart's rhythm
- Blood pressure and pulse checks, sometimes lying down and then standing
- A urine test, or measuring how much urine you pass
- Swabs from any burn marks if infection is suspected
- A scan of the brain in rare cases where a seizure or confusion has happened
What to expect at your appointment
Care usually starts with fluids, monitoring and tests. You may need to stay in hospital for a few hours or overnight so your salt levels and heart rhythm can be watched. Staff will ask detailed questions — please answer honestly, even if you feel embarrassed or worried about the legal side; rules vary between countries and your safety comes first.
Treatment
Treatment aims to support your body while it recovers and to correct problems such as dehydration, low salt levels and changes in heart rhythm. There is no antidote for kambo, so care is based on your symptoms and how serious they are.
Self-care at home
- Do not take part in another kambo session
- Sip fluids slowly and often — an oral rehydration solution from a pharmacy replaces salt as well as water
- Avoid alcohol and strenuous exercise for a day or two
- Keep burn marks clean, dry and covered, and watch for signs of infection
- Ask someone to stay with you for the first 24 hours
- Write down your symptoms and when they started, so you can tell a doctor or nurse
Medical treatments
In hospital, care may include fluids given through a drip to treat dehydration, close monitoring of heart rate, blood pressure and salt levels, oxygen if needed, and treatment for seizures or heart rhythm problems. Antibiotics may be needed if a burn becomes infected. How much treatment you need depends on how serious the reaction is, and most people improve steadily with supportive care.
When is surgery considered?
Surgery is not part of treating kambo reactions. Occasionally a badly infected burn may need cleaning or dressing by a specialist team.
Living with this condition
Most people feel back to normal within a day or two, though some feel tired, shaky or emotionally raw for longer. Take things slowly, rest when you need to, and tell someone you trust how you are feeling.
Lifestyle tips
- Eat and drink normally as soon as you feel able
- Return to gentle movement first, and save intense exercise until you feel strong
- Be cautious about online 'detox' claims — your liver and kidneys already clear waste from your body
- If you are seeking help for a health condition, ask your doctor about treatments that have been properly tested
- Check the rules where you live, as kambo is regulated or restricted in some countries
Diet and exercise
No special diet is needed. If you have been vomiting, replace fluids and salts with small, frequent sips, then go back to normal meals. Wait until the dizziness and weakness have passed before returning to intense exercise.
Mental health and emotional wellbeing
Some people try kambo because they feel stuck, anxious or low, and ceremonies can feel very intense. Strong emotions afterwards are common and understandable. If you feel low, panicky or unsafe, tell someone you trust and speak to your doctor — support is available and you deserve it. If you ever have thoughts of harming yourself, contact your local emergency number or a crisis line in your country straight away.
Prevention
Yes. The surest way to avoid harm is not to use kambo. If someone offers it to you, ask what training and medical support they have, and remember that no one can predict who will have a serious reaction. It is particularly unsafe if you have a heart condition, low blood pressure, epilepsy or kidney disease, or if you are pregnant or breastfeeding.
Screening programmes
There is no test that can tell you in advance whether you would react badly, so screening is not a safe way to decide whether to take part.
Complications
If left untreated
- Dangerously low salt (sodium) levels in the blood, which can cause confusion, seizures and brain swelling
- Severe dehydration and kidney problems
- Irregular heartbeats and, rarely, cardiac arrest
- Breathing difficulty from swelling of the airways
- Infected burns, blistering and permanent scarring
- Panic, distress or low mood afterwards
- Death — deaths have been reported after kambo, including in people who were previously well
Long-term outlook
Most people who get medical help quickly make a full recovery, and serious problems are uncommon. The most important message is that you still have choices: if you are considering kambo, talk to a doctor or pharmacist first, and remember that safer, well-tested treatments exist for most health conditions.
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Always verify with your doctor
Health guidance differs by country and region. This page is general education and may not match the guidelines, medicines, or practice where you live. Discuss your concerns with your own doctor or healthcare provider, and follow local guidance where it exists.
Important notice This information is for educational purposes only. It does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider about your specific situation. If you are experiencing a medical emergency, call your local emergency services immediately.
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Sources and guidance
No guideline names this topic
No health guideline or clinical chapter that names this exact topic is cited here. This page is for general education and information only. It is not a diagnosis, a treatment plan, or personal medical advice. Check with your own doctor and follow their advice. If symptoms are severe, sudden, or worrying, get medical care promptly, and call your local emergency number in an emergency. Ruqelo LLC is not responsible for medical or legal outcomes from decisions based on this information.
Last updated: October 24, 2026
Educational note: This information is for education only and is not a diagnosis.
Use it to support, not replace, advice from a licensed clinician.
If symptoms are severe, worsening, or urgent, call your local emergency number or seek emergency care.
Guidance may differ by country or region. Confirm local recommendations with a qualified healthcare provider.