Diagnostics·Diagnostics
Indirect Coombs test
Informed by recognized medical guidance
Overview
The indirect Coombs test (also called the indirect antiglobulin test) is a blood test that checks for certain antibodies floating in your blood. Antibodies are proteins your immune system makes to fight off foreign substances. This test looks for antibodies that might attack red blood cells, which can cause problems during blood transfusions or pregnancy. The test is done on a sample of your blood, not on you directly.
Key facts
- The indirect Coombs test helps find antibodies that can make red blood cells break down too early (hemolysis).
- It is commonly used before blood transfusions to make sure donor blood is compatible with yours, and during pregnancy to detect antibodies that could affect the baby.
- A positive result means antibodies are present, but does not always mean there is a current problem; further tests may be needed.
This test is very common in hospital labs. It is routinely done for pregnant women, people needing blood transfusions, and sometimes for other medical conditions.